PRODUCTS

Cenexi offers more than 25 years of site experience in sterile liquid and lyophilized fill-finish, including capabilities and capacity for oncology products. We have considerable expertise in manufacturing both development phase, as well as commercialized oncology products in multiple dosage forms.

LIQUID & LYOPHILIZED STERILE FILL-FINISH

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Oncology Prefilled Syringes

Our Thissen plant in Belgium has significant experience with the production of oncology products, with recent expansion into prefilled syringes to complete the cytotoxic offering.

Capabilities
  • Sterile filling with RABs
  • Syringes from 1 to 50 ml
  • Syringes with or without safety devices
Equipment
  • Gröninger / SPC filling machine
  • Ready for éris® safety device
  • Corima labeling machine
Annual Capacity
15M
SYRINGES

Oncology Sterile Vials and Freeze-dried Products

Cenexi’s Thissen site has over two decades of experience with manufacture of freeze-dried oncology products. Along with our Sterile Product Development Center (SPDC), Cenexi is able to produce both established products and those in development.

Capabilities
  • Vials from diameter 16 to 52 mm
  • High speed filling line in A class
  • 6 freeze driers with a surface area of 90 m²
Equipment
  • Libra Hydra washing machine
  • Libra Blue Galaxy sterilization tunnel
  • Farmomac F57 filling machine
  • Usifroid & Knies freeze driers
  • Gröninger KVK108 sealing machine
Annual Capacity
8M
VIALS

Ampoules

Cenexi produces worldwide and has one of the highest production rates in Europe. Today’s industry standards increasingly require the use of high-technology optical controls such as high-frequency or high-voltage detection, which enables reliable, precise and non-destructive inspection of ampoules.

Capabilities
  • SAP - controlled process
  • Aseptic filling
  • Type C ampoules, labeled or silk-screen printed
  • Formats: 1ml / 2ml / 3ml / 5ml / 6ml / 10ml / 20 ml and 25ml
Equipment
  • Bosch filling lines
  • Bausch & Ströbel filling lines
  • Fedegari autoclaves
  • Eisai high-throughput optical control lines
  • Microcrack control on the Nikka Densok HDB and Bosch KLD lines
Annual Capacity
300M
AMPOULES

LIQUID & SOLID DOSAGE FORMS

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Tablets

Cenexi has extensive experience with all major oral solid dosage form types. Our expertise includes special processes and tablet forms including high potency products, sustained-release products, single-pot granulation, double-core tablets, narcotics, etc.

Capabilities
  • Direct compression
  • Aqueous granulation
  • Alcoholic granulation
  • Tableting
  • Film-coating and sugar coating
Equipment
  • Bertrams, Diosna, Moritz
  • Glatt
  • Fette, Korsch
  • Glatt Coater, Manesty
Annual Capacity
3B
TABLETS

Hard Gelatin Capsules

Cenexi has significant expertise with hard gelatin capsule and utilizes IMATIC machines to dose the powder or pellets during capsule filling. These machines are fitted with a single continuously rotating turret that processes the capsules during the various phases of filling. The Precisa units are automated machines designed for 100% mass control of the filled capsules.

Capabilities
  • All capsule formats available
  • Powder and pellets filling
  • 100% mass control
Equipment
  • Bertrams, Diosna, Moritz
  • Glatt
  • Imatic 120, Imatic 150
  • Sc500, Scv 1600
  • Precisa 120, Precisa 16 (mass control)
Annual Capacity
1B
CAPSULES

Hormone Solid Forms

Cenexi’s hormone and high-potency production unit built in 2003 is FDA approved. Cenexi also operates a medium-sized spray dryer that is completely dedicated to hormone production.

Capabilities
  • Dry granulation
  • Wet granulation
  • Tableting
  • Coating
  • Hard gelatin capsule filling
  • Packaging in blisters or tubes
Equipment
  • Bohle, Lodige, Niro Colette
  • Ima
  • Kilian
  • Accelacota, Driam
Annual Capacity
1B
TABLETS

Suppositories

Cenexi has installed a dedicated and qualified line for suppository manufacture, filling and packaging. Cenexi also provides new manufacturing and holding tanks with cleaning-in- place (CIP). For oxidation-sensitive products, Cenexi also offers operations under vacuum or nitrogen.

Capabilities
  • Aluminum or PVC primary packaging
  • Peal-off opening system or pre-sliced
  • Equipment designed for suspensions
Equipment
  • Becomix RW320 & Becomix MH 650
  • Sarong SAS 9
  • Marchesini BA 50
Annual Capacity
80M
ITEMS

Syrups [Thissen]

With two separate syrup manufacturing facilities at Cenexi’s Thissen plant, we can assist you with all your syrup needs, whatever the batch size.

Capabilities
  • Bottles from 125 to 150 ml
  • Glass or plastic bottles
  • 5,000-l manufacturing tank
  • Manufacturing under nitrogen
Equipment
  • Farmomac F57 filling machine
  • Neri labelling machine
  • Flexa cartoning machine
Annual Capacity
23.5M
BOTTLES

Syrups [Fontenay]

Cenexi offers syrup filling in class D rooms and terminal HEPA filtration.

Capabilities
  • Bottles from 50 to 125ml
  • Glass bottles
  • Plastic bottles
Equipment
  • 2,500-l preparation tanks
  • 1,000-l preparation tanks
  • 400-l preparation tanks
  • Farmomac f 640 filling and stoppering machine
  • Cip-sip System
Annual Capacity
10M
BOTTLES

PACKAGING

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Cenexi offers 15 high-throughput packaging lines that enable us to supply a full range of tubes, bottles and blister packs. Pharmaceutical safety is ensured by the bar-code traceability of each component.

Solid Doses

Product Packaged

  • Tablets
  • Capsules
  • Soft Capsules

Equipment

  • IMA
  • Uhlmann
  • Swiftpack
  • King

Packaging Type

  • AL-AL, PVC-AL, Tristar-AL
  • blister packs
  • Plastic tubes and bottles
Ampoules

Product Packaged

  • Ampoules
  • Syringes

Equipment

  • Farcon
  • Dividella

Packaging Type

  • PVC blister packs
  • Dividella Carton
Suppositories

Product Packaged

  • Suppositories
  • Pessaries

Equipment

  • Sarong
  • Marchasini BA 50

Packaging Type

  • Aluminum
  • PVC
Syrups

Product Packaged

  • Bottles

Equipment

  • IMA
  • Marchasini BA 400

Packaging Type

  • Plastic and Glass
Vials

Product Packaged

  • Vial
  • Lyo

Equipment

  • CAM

Packaging Type

  • PVC Blister
  • Carton folding box